The poison of the “black widow” is dangerous because of the neurotoxin in its composition, called α-latrotoxin. German researchers have studied its structure in detail in order to understand whether this substance can be used in medicine.
When the poison of the Black Widow enters the body, the neurotoxin spreads through the human lymphatic system, as a result of which there is a spasm of the abdominal muscles, vomiting, profuse sweating and thirst. However, with proper treatment, the disease usually ends with a complete recovery. However, cases where the poison of the Black Widow has led to death, cause controversy about their veracity.
The exact structure of the nerve agent that makes up the poison (α-latrotoxin) was previously unknown, but it was studied in detail by researchers from the Wilhelm University of Westphalia.
To understand the structure of this toxin, German scientists turned to cryo-electron microscopy technology, the essence of which is the placement of samples of the toxin in liquid nitrogen. This allows you to make several hundred pictures of proteins that make up the structure of the toxin and study them in detail.
The new information will help to understand the procedure for further research on how α-latrotoxin can be used in medicine, as well as to develop a new antidote.