Did you know that the placenta of a newborn is home to life-saving stem cells like ‘lymphoma and leukemia’? For this reason, parents nowadays choose the option of collecting blood in the umbilical cord of the baby. However, if the pregnancy is affected by gestational diabetes, the stem cells of the placenta are damaged and the placenta becomes dysfunctional. Now bioengineers from the University of Notre Dame have described a strategy in their study, which can repair damaged stem cells, so that they can grow new tissue again. Under this strategy, each damaged stem cell is given a nanoparticle backpack.
Study Each spherical nanoparticle 150 nanometers in diameter has the ability to store the drug and slowly transfer it to stem cells.
Donnie Hanjay, Assistant Professor of Aerospace and Mechanical Engineering in the Bioengineering Graduate Program at Notre Dame Told That every stem cell is like a soldier. It is smart and effective. It knows where to go and what to do. But the ‘soldiers’ we are working with are weak. By giving them nanoparticle ‘backpacks’, we are preparing them to work effectively.
Researchers also removed the ‘backpack’ and experimented on damaged cells. It turned out that the cells formed incomplete tissues. At the same time, using the ‘backpack’, the cells also made new blood vessels. Hanjay said his study is the most developed part of any method developed so far. He said that injecting the drug directly into the blood carries the potential for various risks and side effects.
Hanjay and his team think this method may come in handy during pregnancy complications such as preeclampsia. The researcher said that instead of discarding stem cells in the future, we hope that doctors will be able to use them to revive and regenerate the body. He explained by citing examples that a premature baby due to preeclampsia has to stay in the NICU with half-depleted lungs. Our technology can improve a child’s development.