We are talking about modeling the neural processes of memory formation in the hippocampus and entorhinal cortex of the human brain. To study these processes, 27 patients were implanted with electrodes to record the activity of neurons when participants in the study performed memorization tasks. We identified 103 neurons, the firing frequency of which was associated with the successful formation of episodic memory, which is responsible for memories of personal experience, including the place and time of events.
Neurons showed important activity both when patients memorized information and when they tried to extract it from memory. And here it was found that this activity has to do with how the brain distinguishes old memories from new ones, and with respect to epilepsy and schizophrenia, how it distinguishes delusion from reality.
It has been shown to be influenced by the peak neuronal activity associated with the hippocampal theta wave phase, but this phase shifts between memory encoding and recollection.