As noted by Dirk Bumann, head of the study, after antibiotic treatment, about one in 100 bacteria can survive. In order to find out where such bacteria are located in the body, scientists used a special method – sequential two-photon tomography.
In a study of the spleen of mice infected with typhoid fever, researchers found that salmonella are hiding exactly where they should be caught with antibiotics. It is a red or white pulp of the spleen. In this case, there are too few substances in the white pulp that help antibiotics to destroy pathogenic bacteria. Therefore, in this area, treatment is less effective.