This connection was discovered by researchers led by the head of the neurology department of the institute, Kirill Martemyanov, back in 2018. But now the research has continued.
Scientists have studied the biology of the receptor and found that patients with stress or depression have a high concentration of GPR158 in brain cells. Experiments in mice confirmed that those animals that were stressed had an accumulation of the GPR158 receptor in the brain. Blocking it led to calmness.
In the future, scientists hope to develop therapeutic agents based on blocking GPR158 for treating depression and getting rid of stressful conditions.